FMOC PROTECTED PEPTIDE MIMETIC BASED ON A CYCLOHEXANE FRAMEWORK AND INCORPORATION INTO ANGIOTENSIN-II

Authors
KUHN C LINDEBERG G GOGOLL A HALLBERG A SCHMIDT B
Citation
C. Kuhn et al., FMOC PROTECTED PEPTIDE MIMETIC BASED ON A CYCLOHEXANE FRAMEWORK AND INCORPORATION INTO ANGIOTENSIN-II, Tetrahedron, 53(37), 1997, pp. 12497-12504
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
37
Year of publication
1997
Pages
12497 - 12504
Database
ISI
SICI code
0040-4020(1997)53:37<12497:FPPMBO>2.0.ZU;2-W
Abstract
1,3,5-syn substituted cyclohexane based amino acids have been prepared and incorporated into synthetic peptides to serve as scaffold mimicki ng the Val-Tyr-Ile sequence of angiotensin II. The conformationally co nstrained tripeptide mimetic holds potential use as a gamma-turn repla cement. (C) 1997 Elsevier Science Ltd.