A RAPID, MILD AND ACID-FREE PROCEDURE FOR THE PREPARATION OF ACYL CHLORIDES INCLUDING FORMYL CHLORIDE

Authors
VILLENEUVE GB CHAN TH
Citation
Gb. Villeneuve et Th. Chan, A RAPID, MILD AND ACID-FREE PROCEDURE FOR THE PREPARATION OF ACYL CHLORIDES INCLUDING FORMYL CHLORIDE, Tetrahedron letters, 38(37), 1997, pp. 6489-6492
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
37
Year of publication
1997
Pages
6489 - 6492
Database
ISI
SICI code
0040-4039(1997)38:37<6489:ARMAAP>2.0.ZU;2-H
Abstract
Carboxylic acids are converted by hexachloroacetone and triphenylphorp hine at -78 degrees C in methylene chloride to the corresponding acyl chlorides. Formic acid can be used to generate formyl chloride at -78 degrees C in order to perform formylation under very mild conditions. (C) 1997 Elsevier Science Ltd.