ORGANOMETALLIC-TYPE REACTIONS IN AQUEOUS-MEDIA MEDIATED BY INDIUM - ALLYLATION OF ACYLOYL-IMIDAZOLES AND PYRAZOLES - REGIOSELECTIVE SYNTHESIS OF BETA-GAMMA-UNSATURATED KETONES

Authors
BRYAN VJ CHAN TH
Citation
Vj. Bryan et Th. Chan, ORGANOMETALLIC-TYPE REACTIONS IN AQUEOUS-MEDIA MEDIATED BY INDIUM - ALLYLATION OF ACYLOYL-IMIDAZOLES AND PYRAZOLES - REGIOSELECTIVE SYNTHESIS OF BETA-GAMMA-UNSATURATED KETONES, Tetrahedron letters, 38(37), 1997, pp. 6493-6496
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
37
Year of publication
1997
Pages
6493 - 6496
Database
ISI
SICI code
0040-4039(1997)38:37<6493:ORIAMB>2.0.ZU;2-3
Abstract
Indium mediated coupling of allylic bromide with acyloyl-imidazoles or pyrazoles in aqueous media gives the corresponding tertiary alcohols or ketones in good yield. The reaction provides a facile regioselectiv e synthesis of beta,gamma-unsaturated ketones and its usefulness is de monstrated by the synthesis of the monoterpene artemesia ketone. (C) 1 997 Elsevier Science Ltd.