RAPID METHOD FOR DETECTING PAPAVERINE IN BIOLOGICAL-FLUIDS BY PLASMA DESORPTION MASS-SPECTROMETRY WITH IONIZATION BY CF-252 FISSION FRAGMENTS

Authors
CHIVANOV VD EREMENKO IA AKSENOV SA GREBENIK LI EREMENKO VI KALINICHENKO TG TATARINOVA VI ZDOIMA NG SKLYAROVA ZV KURAEV VV KNYSH AN MISHNEV AK
Citation
Vd. Chivanov et al., RAPID METHOD FOR DETECTING PAPAVERINE IN BIOLOGICAL-FLUIDS BY PLASMA DESORPTION MASS-SPECTROMETRY WITH IONIZATION BY CF-252 FISSION FRAGMENTS, Journal of analytical chemistry, 52(9), 1997, pp. 902-905
Citations number
28
Categorie Soggetti
Chemistry Analytical
Journal title
Journal of analytical chemistry → ACNP
ISSN journal
10619348
Volume
52
Issue
9
Year of publication
1997
Pages
902 - 905
Database
ISI
SICI code
1061-9348(1997)52:9<902:RMFDPI>2.0.ZU;2-H
Abstract
Time-of-flight mass spectrometry with bombardment by Cf-252 fission fr agments is a very promising method for the rapid detection of pharmaco logically active and narcotic alkaloids in body fluids. The lowest con centrations of Papaverine, employed as a typical alkaloid, determined in rat blood and urine make up 100 +/- 20 ng. The detection procedure involves a simple two-step cleanup (with a saturated aqueous solution of oxalic acid and chloroform) followed by measuring mass spectra of s olid samples obtained by drying multicomponent biomatrices representin g chloroform extracts from blood or urine on a metal support.