Fy. Jiao et al., RANDOMIZED, CONTROLLED TRIAL OF HIGH-DOSE INTRAVENOUS PYRIDOXINE IN THE TREATMENT OF RECURRENT SEIZURES IN CHILDREN, Pediatric neurology, 17(1), 1997, pp. 54-57
To determine the efficacy of pyridoxine in treating seizures, 90 infan
ts and children with recurrent convulsions primarily due to acute infe
ctious diseases were enrolled iu the present study, Forty patients wer
e treated with high-dose pyridoxine (30 or 50 mg/kg/day) by intravenou
s infusion, and 50 subjects served as controls, Antiepileptic dregs an
d other therapies were similar in the two groups except for pyridoxine
, Clinical efficacy criteria were based on the frequency of convulsion
s per day and on the duration of individual seizures after therapy was
initiated, The results indicated that total response rates in the pyr
idoxine group and control group were 92.5% and 64%, respectively (chi-
square = 14.68, P <.001), After initiation of therapy, seizures resolv
ed after 2.4 +/- 1.4 days in the pyridoxine group and after 3.7 +/- 2.
0 days in the control group (t = 3.67, P <.001), No adverse effects of
pyridoxine were apparent during the observation period, We conclude t
hat pyridoxine is an effective, safe, well-tolerated, and relatively i
nexpensive adjunct to routine antiepileptic drugs for treatment of rec
urrent seizures in children, (C) 1997 by Elsevier Science Inc, All rig
hts reserved.