ENANTIOSELECTIVE TOTAL SYNTHESIS OF THE (-)-(6R,11R,14S)-ISOMER OF COLLETALLOL

Authors
AMIGONI SJ TOUPET LJ LEFLOCH YJ
Citation
Sj. Amigoni et al., ENANTIOSELECTIVE TOTAL SYNTHESIS OF THE (-)-(6R,11R,14S)-ISOMER OF COLLETALLOL, Journal of organic chemistry, 62(18), 1997, pp. 6374-6378
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of organic chemistry → ACNP
ISSN journal
00223263
Volume
62
Issue
18
Year of publication
1997
Pages
6374 - 6378
Database
ISI
SICI code
0022-3263(1997)62:18<6374:ETSOT(>2.0.ZU;2-H
Abstract
The total synthesis of the (-)-(6R,11R,14S)-isomer of colletallol was achieved in 15 steps. The key steps of the sequence were the building of the macrocycle via two consecutive Wittig reactions, the first inte rmolecular and the second intramolecular, instead of the classical mac rolactonization methods.