The extensive computerisation of Danish pharmacies has permitted the e
stablishment of two large prescription registries: The Odense Universi
ty Pharmacoepidemiological Database (OPED) and the Pharmacoepidemiolog
ical Prescription Database of North Jutland (PDNJ). The Danish prescri
ption registries content, coverage, completeness and the quality of th
e data are discussed in this article. Furthermore, conditions for acce
ss to the data are presented. The two prescription registries cover a
background population of approximately one million or 18% of the Danis
h population. The populations covered by the registries are stable and
representative of the Danish population in general. The registries co
ver all reimbursed medicine at the level of the individual user. Regis
tration of a unique and permanent personal identifier enables the comp
ilation of longitudinal drug histories and allows the linking of presc
ription data to other population-based Danish registries. The degree o
f completeness of the Danish prescription registries is excellent for
reimbursed prescription drugs. A small number of comparison studies al
so indicate high validity of the register information. The Danish pres
cription registries represent a useful new data source for pharmacoepi
demiological studies.