MONOCLONAL-ANTIBODIES IN DRUG TARGETING

The objective of drug targeting is to deliver drugs to a specific site of action through a carrier system. in cancer chemotherapy, cytotoxic drugs kill cancerous cells but also damage normal cells. Monoclonal a ntibodies generated against specific antigens, when conjugated to cyto toxic drugs, can selectively deliver drugs to cancer cells while minim izing damage to normal cells. Of all the carrier systems available, mo noclonal antibodies are gaining importance because of their high speci ficity. The purpose of this review is to provide a comprehensive accou nt of the use of monoclonal antibodies in drug targeting, highlighting their scope and limitations.