La. Cowan et al., EFFECT OF STANOZOLOL ON BODY-COMPOSITION, NITROGEN-BALANCE, AND FOOD-CONSUMPTION IN CASTRATED DOGS WITH CHRONIC-RENAL-FAILURE, Journal of the American Veterinary Medical Association, 211(6), 1997, pp. 719
Objective - To determine the effect of stanozolol on body composition,
nitrogen balance, and food consumption in castrated dogs with chronic
renal failure. Design - Blinded crossover trial. Animals - 22 castrat
ed Beagles with experimentally induced chronic renal failure. Procedur
e - Dogs were divided into 2 groups of 11 dogs each. During each of tw
o 6-week treatment periods, dogs in 1 group received stanozolol, and t
hose in the other group received a control agent. Nitrogen balance, bo
dy composition, and food consumption were determined. Results - During
administration of stanozolol, the amount of food consumed per dog, le
an body mass, and nitrogen balance increased. Stanozolol did not have
a significant effect on body fat, bone mineral content, or food consum
ption per kilogram of body weight. Clinical Implications - For dogs wi
th mild-to-moderate, nonuremic, experimentally induced, chronic renal
failure, stanozolol had positive effects on nitrogen balance and lean
body mass.