INFLUENCE OF ALKYL LENGTH IN THE MISCIBILITY OF SEVERAL TYPES OF LECITHINS - INTERACTION OF DOXORUBICIN WITH THESE MEMBRANE MODELS

In the present work the miscibility of four lecithins, dipalmitoyl pho sphatidylcholine (DPPC), palmitoyl oleoyl phosphatidylcholine (POPC), dioleoyl phosphatidylcholine (DOPC) and dihexanoyl phosphatidylcholine (DHPC), were studied as well as interaction of two antracycline antib iotics, doxorubicin and epirubicin, with these model membranes. The mi scibility of these lecithins did not present deviations from ideal beh aviour. The interaction has been studied using compression isotherms o f monolayers and penetration kinetics. Doxorubicin and epirubicin show medium surface activity, saturation was reached at 10 mu M concentrat ion for both antracycline antibiotics under monolayers did not modify the shape of compression isotherms.