ANTIOXIDANT STATUS OF LIVER, ERYTHROCYTES, AND BLOOD-SERUM OF RATS INACUTE METHANOL INTOXICATION

SOD, CAT, GSH-Px, GSSG-R, ascorbic acid, alpha-tocopherol, nonprotein- and protein-bound sulfhydryl compounds, and TBA-rs content in the live r, erythrocytes, and blood serum of rats treated with methanol after 6 , 12, and 24 h and 2, 5, and 7 days were investigated. Furthemore, hem atological parameters of erythrocytes were analysed, GSH-Px, GSSG-R, s ulfhydryl compounds, and ascorbic acid in the liver, erythrocytes, and in blood serum were significantly decreased. In addition, Cu,Zn SOD a nd tocopherol in erythrocytes were diminished, whereas TBA-rs in the t hree biological materials was enhanced. Simultaneously, erythrocytes a mount, hemoglobin level, hematocrit, and MCV were reduced. These resul ts indicate that methanol in rats leads to the impairment of antioxida nt mechanisms in the liver, erythrocytes, and blood serum. (C) 1997 El sevier Science Inc.