TRANSITION-METAL SACCHARIDE CHEMISTRY AND BIOLOGY - VANADYL-MONOSACCHARIDE COMPLEXES AND THEIR IN-VITRO EFFECT ON PUC-18 DNA

Solid state complexes of VO2+ were synthesized from methanolic solutio ns of VOCl2 and sodium salt of the hexoses (D = Glc, D-Fra, D-Gal) and pentoses (D-Xyl, D-Rib). The complexes were characterized by diffuse reflectance, aqueous solution absorbance, CD, FTIR, EPR spectroscopies , CV, and elemental analysis. The complexes were found to be mononucle ar with a general formula, Na-2[VO(Sacch)(2)(OH)Cl] and these are diff erent those reported earlier which were synthesised by a different rou te. The aqueous solution stability and pH variation studies of these c omplexes have shown formation of polymeric species as monitored by UV- visible absorption spectroscopy and cyclic voltammetry. All the comple xes exhibited enhanced structural alterations of pUC-18 DNA in the pre sence of hydrogen peroxide, based on in vitro studies. (C) 1997 Elsevi er Science Inc.