Rj. Delfino et al., THE EFFECT OF OUTDOOR FUNGAL SPORE CONCENTRATIONS ON DAILY ASTHMA SEVERITY, Environmental health perspectives, 105(6), 1997, pp. 622-635
The relationship between day-to-day changes in asthma severity and com
bined exposures to community air pollutants and aeroallergens remains
to be dearly defined. We examined the effects of outdoor air pollutant
s, fungi, and pollen on asthma. Twenty-two asthmatics ages 9-46 years
were followed for 8 weeks (9 May-3 July 1994) in a semirural Southern
California community around the air inversion base elevation (1,200 ft
). Daily diary responses included asthma symptom severity (6 levels),
morning and evening peak expiratory flow rates (PEFR), and as-needed b
eta-agonist inhaler use. Exposures included 24-hr outdoor concentratio
ns of fungi, pollen, and particulate matter with a diameter <10 mu m (
PM10; maximum = 51 mu g/m(3)) and 12-hour day-time personal ozone (O-3
) measurements (90th percentile = 38 ppb). Random effects longitudinal
regression models controlled for autocorrelation and weather. Higher
temperatures were strongly protective, probably due to air conditionin
g use and diminished indoor allergens during hot, dry periods. Control
ling for weather, total fungal spore concentrations were associated wi
th all outcomes: per minimum to 90th percentile increase of nearly 4,0
00 spores/m(3), asthma symptom scores increased 0.36 (95% CI, 0.16-0.5
6), inhaler use increased 0.33 puffs (95% CI, -0.02-0.69),and evening
PEFR decreased 12.1 l/min (95% CI, -1.8-22.3). These associations were
greatly enhanced by examining certain fungal types (e.g., Alternaria,
basidiospores, and hyphal fragments) and stratifying on 16 asthmatics
allergic to tested deuteromycete fungi. There were bo significant ass
ociations to low levels of pollen or O-3, but inhaler use was associat
ed with PM10 (0.15 inhaler puffs/10 mu g/m(3); p<0.02). These findings
suggest that exposure to fungal spores can adversely effect the daily
respiratory status of some asthmatics.