Exocytosis of synaptic vesicles is followed rapidly by reinternalizati
on and recycling of their membranes. Recent studies have confirmed the
key role of clathrin-mediated endocytosis in synaptic vesicle reforma
tion and have identified new proteins that participate in this process
. In addition, growing evidence suggests that lipids, primarily phosph
oinositides, play an important role in synaptic vesicle recycling.