VISION-THREATENING COMPLICATIONS OF SURGERY FOR FULL-THICKNESS MACULAR HOLES

Citation
As. Banker et al., VISION-THREATENING COMPLICATIONS OF SURGERY FOR FULL-THICKNESS MACULAR HOLES, Ophthalmology, 104(9), 1997, pp. 1442-1452
Citations number
25
Categorie Soggetti
Ophthalmology
Journal title
ISSN journal
01616420
Volume
104
Issue
9
Year of publication
1997
Pages
1442 - 1452
Database
ISI
SICI code
0161-6420(1997)104:9<1442:VCOSFF>2.0.ZU;2-Z
Abstract
Objective: To study complications of vitrectomy surgery for full-thick ness macular holes. Design: A multicentered, randomized, controlled cl inical trial. Participants: Community and university-based ophthalmolo gy clinics. Intervention: Standardized macular hole surgery versus obs ervation. Main Outcome Measures: Assessment of anatomic and visual out comes and determination of postoperative complications at 12 months af ter randomization. Results: Posterior segment complications were noted in 39 eyes (41%). The incidences of retinal pigment: epithelium (RPE) alteration and retinal detachment (RD) were 33% and 11%, respectively . One RD due to a giant retinal tear resulted in a visual acuity of li ght perception. Other complications included a reopening of the macula r hole in 2 eyes (2%), cystoid macular edema in 1 eye (1%), a choroida l neovascular membrane in 1 eye (1%), and endophthalmitis in 1 eye (1% ). Eyes with complications had significantly worse visual acuity outco mes as determined by the Early Treatment Diabetic Retinopathy Study, W ord Reading, and Potential Acuity Meter charts (P < 0.01 for all compa risons). Eyes with macular holes greater than 475 mu m were more than twice as likely to have complications than eyes with holes less than 4 75 mu m (odds ratio [OR] = 2.2, P = 0.07). Before surgery, the stage o f the hole was related to postoperative RPE changes (P < 0.0001) and t he occurrence of postoperative RD (P = 0.0002). Intraoperative trauma was related to the occurrence of these complications (P < 0.0001 for R PE changes, P = 0.02 for RDs). Epiretinal membrane removal was related to RPE changes (P = 0.02) but not RDs. Conclusions: The RPE alteratio ns and RDs are common after macular hole surgery and result in signifi cantly reduced postoperative visual acuity. The RPE changes may be rel ated to surgical trauma or light toxicity, Further efforts to reduce c omplications associated with macular hole surgery are indicated.