A PILOT-STUDY OF MEGESTROL-ACETATE AND IBUPROFEN IN THE TREATMENT OF CACHEXIA IN GASTROINTESTINAL CANCER-PATIENTS

Authors
MCMILLAN DC OGORMAN P FEARON KCH MCARDLE CS
Citation
Dc. Mcmillan et al., A PILOT-STUDY OF MEGESTROL-ACETATE AND IBUPROFEN IN THE TREATMENT OF CACHEXIA IN GASTROINTESTINAL CANCER-PATIENTS, British Journal of Cancer, 76(6), 1997, pp. 788-790
Citations number
18
Categorie Soggetti
Oncology
Journal title
British Journal of Cancer → ACNP
ISSN journal
00070920
Volume
76
Issue
6
Year of publication
1997
Pages
788 - 790
Database
ISI
SICI code
0007-0920(1997)76:6<788:APOMAI>2.0.ZU;2-U
Abstract
Advanced gastrointestinal cancer patients with weight loss and an acut e-phase response (n = 15) were given megestrol acetate (480 mg day(-1) ) and ibuprofen (1200 mg day(-1)) for 6 weeks. Overall, there was an i ncrease in body weight (P = 0.01) and a reduction in C-reactive protei n concentrations (P = 0.02), with no change in total body water (P = 0 .24) over this period. This regimen may be an effective non-toxic trea tment for cancer cachexia and is worthy of further study.