RECOVERING OPTIC NEURITIS DURING SYSTEMIC CISPLATIN AND CARBOPLATIN CHEMOTHERAPY

Introduction - We describe bilateral optic neuropathy in a patient aff ected by ovarian carcinoma treated with cis-platin 160 mg/m(2) and car boplatin, 640 mg/m(2). The patient was followed for 1 year, when recov ery appeared. The few previous descriptions of CDDP optic nerve toxici ty did not report recovery. Methods - Computerized visual field, visua l evoked potentials, pattern electoretinograms, full field flash elect roretinograms were recorded during follow-up. Results - Optic neuritis appeared 13 weeks after cis-platin discontinuation, with right eye ce ntral scotoma; 2 days later the patient became bilaterally blind. Visu al evoked potentials were initially absent, reappeared, with delayed l atencies to left eye stimuli at 6 months, in both eyes at 9 months. At 1 year delayed VEPs were recorded with right eye stimuli, normal VEPs were recorded for left eve. Conclusion - Cis-pIatin can induce delaye d optic neuritis, that can recover in 1 year.