LEWIS BASE-CATALYZED TRIFLUOROMETHYLATION OF CARBONYL-COMPOUNDS WITH TRIALKYL(TRIFLUOROMETHYL)SILANES

Authors
HAGIWARA T KOBAYASHI T FUCHIKAMI T
Citation
T. Hagiwara et al., LEWIS BASE-CATALYZED TRIFLUOROMETHYLATION OF CARBONYL-COMPOUNDS WITH TRIALKYL(TRIFLUOROMETHYL)SILANES, Main group chemistry, 2(1), 1997, pp. 13-15
Citations number
10
Categorie Soggetti
Chemistry
Journal title
Main group chemistry → ACNP
ISSN journal
10241221
Volume
2
Issue
1
Year of publication
1997
Pages
13 - 15
Database
ISI
SICI code
1024-1221(1997)2:1<13:LBTOCW>2.0.ZU;2-V
Abstract
Many Lewis bases effectively catalyze the trifluoromethylation of carb onyl compounds with trimethyl(trifluoromethyl)silane. By using chiral Lewis bases as catalysts, asymmetric trifluoromethylation was achieved . The higher enantiomer excesses were observed on using trialkyl(trifl uoromethyl)silanes bearing bulky alkyl groups on the silicon atom.