NEW POLYAZOLE DERIVATIVES FROM 2-(2,4-DICHLOROPHENYL)-1,3-DIOXOLANE -ANTIFUNGAL ACTIVITY - STRUCTURE-ACTIVITY-RELATIONSHIPS

Authors
DELCOURT A MATHIEU G BAJI H KIMNY T FLAMMANG M COMPAGNON PL
Citation
A. Delcourt et al., NEW POLYAZOLE DERIVATIVES FROM 2-(2,4-DICHLOROPHENYL)-1,3-DIOXOLANE -ANTIFUNGAL ACTIVITY - STRUCTURE-ACTIVITY-RELATIONSHIPS, Mycopathologia, 137(1), 1997, pp. 27-32
Citations number
17
Categorie Soggetti
Mycology,Pathology
Journal title
Mycopathologia → ACNP
ISSN journal
0301486X
Volume
137
Issue
1
Year of publication
1997
Pages
27 - 32
Database
ISI
SICI code
0301-486X(1997)137:1<27:NPDF2->2.0.ZU;2-I
Abstract
Six new polyazole derivatives from 2-(2,4-dichlorophenyl)-1,3-dioxolan e were studied for their antifungal activity against pathogenic fungi for humans and animals. The antimycotic effect was largely restricted to the filamentous fungi with Aspergillus fumigatus and Scedosporium a piospermum being remarkably susceptible. Three compounds were as effec tive as the two references, ketoconazole and oxiconazole. The structur e-activity relationships revealed that an 'oxime group' combined with four chlorine atoms increased the antifungal properties of the chemica l series.