THE EFFECT OF SHO-SAIKO-TO ON CONCENTRATION OF VITAMIN-E IN SERUM ANDON GRANULOMA-FORMATION IN CARRAGEENAN COTTON PELLET-INDUCED GRANULOMARATS

The effect of Sho-saiko-to on the concentration of vitamin E in serum and on the granuloma formation in Carrageenin cotton pellet-induced ra ts was investigated. As a result, in the granuloma rats of Sho-saiko-t o group, a significantly improved inhibitory effect on granuloma forma tion and a higher concentration of vitamin E in serum, cholesterol and phospholipid were observed compared to the control group. Despite thi s lipid-increasing action by Sho-saiko-to, the concentration of serum lipid peroxide was significantly lower than in the control group. Furt hermore, a significant negative correlation between the concentration of vitamin E and granuloma weight was observed. These results suggest that vitamin E plays an important role in promoting the anti-inflammat ory effect of Sho-saiko-to.