HORMONAL INHIBITION OF ENDOMETRIUM FOR TRANSCERVICAL ENDOMETRIAL ABLATION - A PROSPECTIVE-STUDY WITH A 2-YEAR FOLLOW-UP

Objective: To determine the best pretreatment of the endometrium prior to roller ball endometrial ablation. Study Design: Forty patients wit h recurrent hypermenorrhea underwent diagnostic hysteroscopy and dilat ation and curettage. They were then assigned to receive either no pret reatment or pretreatment with danazol, a GnRH-analogue, or a gestagen prior to roller ball endometrial ablation. Endometrial suppression was estimated by the surgeon at the time of the procedure, and endometria l biopsies were obtained. Patients were followed for 24 months. Result s: The subjective estimation of the surgeon showed a sufficient pretre atment after danazol or a GnRH-analogue in 90% of the cases. Histologi cal findings correlated with these findings. The highest level of amen orrhoea at 2 years of follow-up was also reached after danazol or GnRH -analogue pretreatment. Conclusions: Danazol-or GnRH analogue should b e used for pretreatment prior to endometrial ablation using the roller ball technique. (C) 1997 Elsevier Science Ireland Ltd.