DOWNS-SYNDROME, EDWARDS-SYNDROME, PATAUS-SYNDROME - SYNTHESIS OF GLYCOSAMINOGLYCANS

Authors
KUKHARENKO V SHELEG S FREUDINE M PICHUGINA E DELVIG A
Citation
V. Kukharenko et al., DOWNS-SYNDROME, EDWARDS-SYNDROME, PATAUS-SYNDROME - SYNTHESIS OF GLYCOSAMINOGLYCANS, Human genetics, 94(1), 1994, pp. 80-82
Citations number
10
Categorie Soggetti
Genetics & Heredity
Journal title
Human genetics → ACNP
ISSN journal
03406717
Volume
94
Issue
1
Year of publication
1994
Pages
80 - 82
Database
ISI
SICI code
0340-6717(1994)94:1<80:DEP-SO>2.0.ZU;2-R
Abstract
Synthesis of glycosaminoglycans (GAGs) by fibroblasts derived from sev en patients with Down's syndrome, five patients with Edwards' syndrome , and two patients with Patau's syndrome were studied in cell culture. The aneuploid strains were compared with diploid fibroblasts from age -matched controls. In terms of hyaluronic acid and sulfated CAG synthe sis, the amount of synthesized hyaluronic acid was not significantly d ifferent between postnatal aneuploid strains and controls.