A TOTAL SYNTHESIS OF THE (5R,8S,13R,16S)-ISOMER OF PYRENOPHOROL

Authors
AMIGONI S LEFLOCH Y
Citation
S. Amigoni et Y. Lefloch, A TOTAL SYNTHESIS OF THE (5R,8S,13R,16S)-ISOMER OF PYRENOPHOROL, Tetrahedron : asymmetry, 8(16), 1997, pp. 2827-2831
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Inorganic & Nuclear","Chemistry Physical
Journal title
Tetrahedron : asymmetry → ACNP
ISSN journal
09574166
Volume
8
Issue
16
Year of publication
1997
Pages
2827 - 2831
Database
ISI
SICI code
0957-4166(1997)8:16<2827:ATSOT(>2.0.ZU;2-D
Abstract
The first total synthesis of the (5R,8S,13R,16S)-isomer 3 of pyrenopho rol is described using a retrosynthetic scheme based on two consecutiv e double bond cleavages. The title compound 3 was prepared in 14 steps with an overall yield of 4.5% starting from the key synthon 6, readil y prepared from (S)-(-)-ethyl lactate. (C) 1997 Elsevier Science Ltd.