LIPOPOLYSACCHARIDE INDUCES SICKNESS BEHAVIOR IN RATS BY A VAGAL MEDIATED MECHANISM

Authors
BLUTHE RM WALTER V PARNET P LAYE S LESTAGE J VERRIER D POOLE S STENNING BE KELLEY KW DANTZER R
Citation
Rm. Bluthe et al., LIPOPOLYSACCHARIDE INDUCES SICKNESS BEHAVIOR IN RATS BY A VAGAL MEDIATED MECHANISM, Comptes rendus de l'Academie des sciences. Serie 3, Sciences de la vie, 317(6), 1994, pp. 499-503
Citations number
17
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Comptes rendus de l'Academie des sciences. Serie 3, Sciences de la vie → ACNP
ISSN journal
07644469
Volume
317
Issue
6
Year of publication
1994
Pages
499 - 503
Database
ISI
SICI code
0764-4469(1994)317:6<499:LISBIR>2.0.ZU;2-M
Abstract
To assess the possibility that lipopolysaccharide (LPS) induces sickne ss behaviour by activating nerves, the effects of LPS (1.25 mg Kg(-1), intraperitoneally) were in vagotomized and sham-operated rats. Subdia phragmatic vagotomy blocked the LPS-induced depression of social inves tigation but had no effect on LPS-induced increases in levels of lL-1 beta in plasma and peritoneal macrophages and on LPS-induced changes i n dehydrogenase activity of peritoneal macrophages.