SIGNIFICANCE OF MULTIMODALITY EVOKED-POTENTIAL ABNORMALITIES IN SARCOIDOSIS

To assess central nervous system (CNS) involvement with normal CNS exa mination, multimodality evoked potentials were obtained in 25 patients with confirmed multisystem sarcoidosis. Twelve patients had abnormal evoked potentials; brainstem auditory evoked potentials (BAEP) were ab normal in 5, median nerve somatosensory evoked potentials (SEP) were a bnormal in 4, and visual evoked potentials (VEP) were abnormal in 6 pa tients. Contrast-enhanced magnetic resonance imaging (MRI) of the brai n in two patients with abnormal evoked potentials revealed no supporti ve structural lesions. Multimodality evoked potentials can detect subc linical neurosarcoidosis and are an important adjunct to neuroradiolog y in the diagnosis of neurosarcoidosis.