ALLELIC IMBALANCE MAPPING OF CHROMOSOME-16 SHOWS 2 REGIONS OF COMMON DELETION IN PROSTATE ADENOCARCINOMA

Allelic imbalance (Al) has now been reported on the long arm of chromo some 16 in several cancers including breast, prostate, hepatocellular carcinoma, and Wilms tumor. Such nonrandom Al is commonly associated w ith the presence of a tumor suppressor gene (TSG) at or near the teste d locus. Previous studies in our laboratory indicated that prostate ca ncer genomes frequently exhibit a region of allelic loss near the q te rminus of chromosome 16. Here we report a detailed, PCR based, allelic imbalance study at ten polymorphic loci on 16q. The data indicate tha t there are two common regions of 16q Al in prostate cancer, one at 16 q21-22 (50% of informative cases) and another at 16q24.2-qter (56% of informative cases). These are similar to regions of 16q previously sho wn to exhibit Alin breast cancer. Neither of these regions shows corre lation of AI with the clinical parameters; Gleason grade, tumor stage, or metastases. (C) Elsevier Science inc., 1997.