DETECTION OF A DUP(17Q) AND INV(16) BY FLUORESCENCE IN-SITU HYBRIDIZATION IN ACUTE MYELOMONOCYTIC LEUKEMIA

Two cases bf acute myelomonocytic leukemia (AMMoL) of FAB type M4Eo ar e described in which a primary subclone containing a dup(17)(q21q25) a nd a subclone containing dup(17)(q21q25), inv(16)(p13q22) were seen in one patient, and -7, dup(17)(q21q25) in another. Fluorescence in situ hybridization (FISH) was carried out for the confirmation of the dupl icated segment and breakpoint of inv(16). Inv(16) is a well known anom aly in AMMoL, whereas dup(17q) is rare though as not yet confirmed, th is anomaly could be a nonrandom or navel change in AMMoL. (C) Elsevier Science Inc., 1997.