DIETARY TRYPTOPHAN AND AGING

This paper considers findings which may relate to whether there may be a correlation between dietary L-tryptophan and aging. Early studies h ad reported that animals fed a tryptophan-deficient diet showed increa sed longevity compared to controls. Although decreased serotonin level s due to the tryptophan-deficient diet was considered of importance fo r the increased longevity, a more likely explanation was decreased die t intake due to the deficient diet. Indeed, decreased diet consumption as well as decreased energy intake have been shown to lengthen the li fespan of animals. Greater quantitative assessment between the effect of a tryptophan-deficient diet and that of decreased energy intake nee ds to be obtained. Our recent findings that one mouse strain (NZBWF(1) ), which is autoimmune susceptible and has a relatively short lifespan , demonstrate a significantly decreased binding affinity for L-tryptop han by hepatic nuclei when compared to other mouse strains are of much interest. These results stimulated us to reconsider the issue whether L-tryptophan itself may influence the aging process. Since L-tryptoph an has a regulatory effect on hepatic protein synthesis which may be r elated to its binding to a specific nuclear receptor, much akin to wha t occurs with certain steroid hormones which are considered to be invo lved in the aging process, this review explores the possibility that L -tryptophan via its regulatory action may be of great importance and m erits further investigation. This indispensible dietary component may have a vital regulatory control in the normal state and possibly also during the process of aging.