A NEW SYNTHESIS OF THE TRIPEPTIDE GLY-HIS-LYS WITH ANTIMICROBIAL ACTIVITY

Authors
LIAKOPOULOUKYRIAKIDES M PACHATOURIDIS C EKATERINIADOU L PAPAGEORGIOU VP
Citation
M. Liakopouloukyriakides et al., A NEW SYNTHESIS OF THE TRIPEPTIDE GLY-HIS-LYS WITH ANTIMICROBIAL ACTIVITY, Amino acids, 13(2), 1997, pp. 155-161
Citations number
18
Categorie Soggetti
Biology
Journal title
Amino acids → ACNP
ISSN journal
09394451
Volume
13
Issue
2
Year of publication
1997
Pages
155 - 161
Database
ISI
SICI code
0939-4451(1997)13:2<155:ANSOTT>2.0.ZU;2-1
Abstract
A new solid phase synthesis of the growth-modulating tripeptide Gly-Hi s-Lys is described. 2-Chlorotrityl chloride resin and 9-fluorenylmetho xycarbonyl-(Fmoc), 4-methyltrityl-(Mtt) protecting groups were used. T he synthetic tripeptide was tested for its activity against bacteria, yeast and fungi. The in vitro effect of the tripeptide on DNA, RNA and protein synthesis was studied as well.