SYNTHESIS AND ACTION ON THE CENTRAL-NERVOUS-SYSTEM OF 3-SUBSTITUTED NYL-2,3-DIHYDRO-4H-1,3,2-BENZOXAZAPHOSPHORIN-4-ONE 2-OXIDE AND 2-SULFIDE DERIVATIVES

Authors
KOSTKA K PORADA M ZYNER E PAKULSKA W SZADOWSKA A
Citation
K. Kostka et al., SYNTHESIS AND ACTION ON THE CENTRAL-NERVOUS-SYSTEM OF 3-SUBSTITUTED NYL-2,3-DIHYDRO-4H-1,3,2-BENZOXAZAPHOSPHORIN-4-ONE 2-OXIDE AND 2-SULFIDE DERIVATIVES, Archiv der pharmazie, 330(7), 1997, pp. 203-206
Citations number
12
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
330
Issue
7
Year of publication
1997
Pages
203 - 206
Database
ISI
SICI code
0365-6233(1997)330:7<203:SAAOTC>2.0.ZU;2-1
Abstract
The synthesis of 3-substituted nyl-2,3-dihydro-4H-1,3,2-benzoxazaphosp horin-4-one 2-sulfide derivatives is described. The action of a series 2-oxide (1-6) and 2-sulfide (7-12) derivatives on the central nervous system has been evaluated. Compounds 1-4, 6, 7-10 exhibit neuroleptic activity. Derivatives of sulfide series act as antiserotoninergic dru gs.