SEARCH FOR NEW ANTIARRHYTHMIC AND HYPOTENSIVE COMPOUNDS - SYNTHESIS, ANTIARRHYTHMIC, ANTIHYPERTENSIVE, AND ALPHA-ADRENOCEPTOR BLOCKING ACTIVITY OF NOVEL 1-[(2-HYDROXY-3-AMINO)]-PROPYLPYRROLIDIN-2-ONE DERIVATIVES

A series of the derivatives of 3-(4-phenyl-1-piperazinyl)propyl]-pyrro lidin-2-one (MG-1) was synthesized and tested for electrocardiographic , antiarrhythmic, and antihypertensive activity as well as for alpha 1 - and alpha(2)- adrenoceptcrrs binding affinities. Some of the compoun ds of this series slightly decreased the heart rate, prolonged P-Q, Q- T intervals and QRS complex. Only compound 7 roxy-3-(4-phenyl-1-pipera zinyl)propyl]-pyrolidine) possesses potent antiarrhythmic and a slight hypotensive properties, and affinity for alpha(1)- and alpha 2- adren oceptor. The results suggest that the antiarrhythmic and hypotensive e ffect of compound 7 and MG-1 is related to their adrenolytic propertie s, and that those properties depend on the presence of a phenylpiperaz ine moiety.