SYNTHESIS AND BONE-RESORPTION EFFECT OF ALKOXY-SUBSTITUTED XANTHONES

Authors
PIFFERI G DARE P VALENTI P BISI A MALANDRINO S
Citation
G. Pifferi et al., SYNTHESIS AND BONE-RESORPTION EFFECT OF ALKOXY-SUBSTITUTED XANTHONES, Archiv der pharmazie, 330(7), 1997, pp. 233-234
Citations number
17
Categorie Soggetti
Chemistry,"Pharmacology & Pharmacy
Journal title
Archiv der pharmazie → ACNP
ISSN journal
03656233
Volume
330
Issue
7
Year of publication
1997
Pages
233 - 234
Database
ISI
SICI code
0365-6233(1997)330:7<233:SABEOA>2.0.ZU;2-W
Abstract
A topological modification of ipriflavone 1, a recent anti-osteoporoti c drug, is described. The flavone moiety of 1 has been replaced by a x anthone one. Among the new derivatives, the 3,6-diisopropoxyxanthone ( 2a) has shown significant bone resorption inhibition in in vitro and i n vivo tests.