E. Alhan et al., EFFECTS OF TOTAL PARENTERAL-NUTRITION USING A SOLUTION ENRICHED WITH BRANCHED-CHAIN AMINO-ACIDS ON EXPERIMENTAL PANCREATITIS IN RATS, European surgical research, 29(5), 1997, pp. 382-389
The main purpose of this study was to investigate the influence of tot
al parenteral nutrition enriched with branched-chain amino acids (BCAA
) on acute pancreatitis (AP) induced by sodium taurocholate in rats. T
otal parenteral nutrition (TPN) increased the survival rate and serum
calcium, and reduced serum ureal liver transaminase? acid phosphatase
and lactate dehydrogenase levels, but it did not change the degree of
pancreatic damage or serum amylase. Total plasma amino acid concentrat
ion and the concentrations of glutamate, glycine, alanine, taurine, va
line, leucine, isoleucine, phenylalanine increased significantly after
the induction of AP, but there was no difference between the control
and therapy groups. Hyperglycemia occurred during the use of TPN. BCAA
-enriched TPN can be used in the treatment of AP with few side effects
.