METHYLENE-BLUE - A PROMISING TREATMENT MODALITY IN SEPSIS-INDUCED BY BOWEL PERFORATION

In this study, we compared the effects of methylene blue (MB) and an L -arginine analogue on host outcome, blood pressure, lung injury, and n itric oxide (NO) production in rats following fecal peritonitis induce d by cecal ligation and puncture (CLP). Sepsis syndrome was induced in 90 rats: 30 were treated with MB, 30 with an NO synthase inhibitor, a nd 30 with normal saline. We found significantly less alveolar damage, higher blood pressure, better respiratory function, and delayed morta lity among animals treated with MB compared to the control group. We c onclude that the ability of MB to reduce alveolar damage and therefore to delay mortality in this animal septic shock model may give this ha rmless substance a role among the treatment modalities of septic shock syndrome induced by fecal peritonitis.