EFFECTS OF CARBON-DIOXIDE PNEUMOPERITONEUM IN PIGS WITH IMPAIRED PULMONARY-FUNCTION

The objective of our study was to investigate the possible adverse hem odynamic effects of a CO2 pneumoperitoneum in an experimental model in pigs with impaired pulmonary function, Thirteen animals were anesthet ized with azaperon/ketamine and ventilated with 67% nitrous oxide in o xygen, By intravenous injection of dextran microspheres, a capillary p ulmonary embolism was induced, After embolization, three animals serve d as controls (Group 1), five underwent open nephrectomy (Group 2), an d five underwent laparoscopic nephrectomy (Group 3), Intra-abdominal p ressure was kept constant at 15 mm Hg. At intervals, hemodynamic param eters were measured, and blood gas measurements were performed, Data w ere analyzed using a general linear model analysis of variance for dif ferences between groups, and a paired t-test was applied for differenc es within groups from one condition to the next, The groupwise compari son revealed a significant rise of cardiac output in the laparoscopy g roup compared with the open nephrectomy group, No differences were not ed for heart rate, systemic arterial pressure, central venous pressure , mean pulmonary arterial pressure, or pulmonary arterial wedge pressu re, Impairment of pulmonary function caused no negative hemodynamic ef fect during laparoscopic nephrectomy.