CHIRAL RESOLUTION OF FLOBUFEN BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND CAPILLARY ELECTROPHORESIS

Authors
TESARVA E GILAR M JEGOROV A UHROVA M DEYL Z
Citation
E. Tesarva et al., CHIRAL RESOLUTION OF FLOBUFEN BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY AND CAPILLARY ELECTROPHORESIS, BMC. Biomedical chromatography, 11(5), 1997, pp. 321-324
Citations number
28
Categorie Soggetti
Chemistry Analytical","Pharmacology & Pharmacy",Biology,"Biochemical Research Methods
Journal title
BMC. Biomedical chromatography → ACNP
ISSN journal
02693879
Volume
11
Issue
5
Year of publication
1997
Pages
321 - 324
Database
ISI
SICI code
0269-3879(1997)11:5<321:CROFBH>2.0.ZU;2-B
Abstract
The enantiomeric separation of an anti-inflammatory drug flobufen was performed on various chiral columns in liquid chromatography and by re versed phase chromatography and by capillary electrophoresis with beta -cyclodextrin as a chiral selector in the mobile phase and background electrolyte, respectively. The elution order of individual enantiomers is discussed with respect to the absolute chirality of (+/-)-flobufen determined by X-ray crystallography. (C) 1997 by John Wiley & Sons, L td.