COMPARISON OF ORAL SODIUM COMPOUNDS FOR THE CORRECTION OF ACIDOSIS

Three Na compounds were tested to determine which was best able to tre at metabolic acidosis in dairy cows. Metabolic acidosis was induced in test cows by feeding a diet that was high in anions for 7 d before th e administration of treatment on d 8. The orally administered treatmen ts were equivalent amounts of Na in the form of NaCl (208.6 g), NaHCO3 (300 g), or Na propionate (343 g). The initiation of oral treatment w as designated as time 0, and blood samples were taken 15 min before tr eatment, immediately before treatment, and 15, 30, 45, 60, 90, 120, 18 0, 240, 300, and 360 mill after treatment. Before treatment, all cows were in a state of metabolic acidosis as was evidenced by low blood pH , low HCO3 concentrations, and high plasma Cl concentrations. After tr eatment, blood pH and HCO3 were markedly higher for cows receiving NaH CO3 and Na propionate but not for cows receiving NaCl. We concluded th at orally administered NaHCO3 and Na propionate were equally effective in correcting the acid-base balance of blood, as was predicted by the strong ion difference theory of acid-base physiology. Sodium propiona te may be considered a more effective treatment of metabolic acidosis in diseases such as ketosis because the added propionate can serve as a source of glucose for the cow.