ENDOTHELIUM-DEPENDENT VASODILATOR EFFECT OF EXTRACT PREPARED FROM THESEEDS OF ARECA-CATECHU ON ISOLATED RAT AORTA

Authors
GOTO H TANAKA N TANIGAWA K SHIMADA Y ITOH T TERASAWA K
Citation
H. Goto et al., ENDOTHELIUM-DEPENDENT VASODILATOR EFFECT OF EXTRACT PREPARED FROM THESEEDS OF ARECA-CATECHU ON ISOLATED RAT AORTA, PTR. Phytotherapy research, 11(6), 1997, pp. 457-459
Citations number
7
Categorie Soggetti
Chemistry Medicinal","Pharmacology & Pharmacy
Journal title
PTR. Phytotherapy research → ACNP
ISSN journal
0951418X
Volume
11
Issue
6
Year of publication
1997
Pages
457 - 459
Database
ISI
SICI code
0951-418X(1997)11:6<457:EVEOEP>2.0.ZU;2-S
Abstract
Arecae semen extract relaxed aortic ring preparations of isolated rat aorta that contained endothelium from 3 x 10(-7) g/mL, reaching a maxi mum of 86% at 10(-5) g/mL, Its relaxation did not occur in specimens w ithout endothelium, and was inhibited by pretreatment with 10(-4) M N- G-nitro-1-arginine methylester, One of the active components was areco line which is a muscarinic receptor agonist. Another active component was condensed tannin contained in Arecae semen. (C) 1997 by John Wiley & Sons, Ltd.