Naltrexone is a pure opioid antagonist that is an effective nonaversiv
e pharmacologic treatment for alcohol dependence. The usual dosage is
50 mg per day. Side effects may include nausea, headache, dizziness an
d arthralgia. Naltrexone appears to exert its effect by decreasing the
craving for alcohol. It has also been useful in allowing some patient
s to decrease their need for other medications, such as benzodiazepine
s and antihypertensives. Naltrexone should be used as an adjunct to a
comprehensive alcohol treatment program that addresses concomitant med
ical problems and psychosocial concerns.