ABNORMALITIES OF AUDITORY-EVOKED MAGNETIC-FIELDS AND STRUCTURAL-CHANGES IN THE LEFT-HEMISPHERE OF MALE-SCHIZOPHRENICS - A MAGNETOENCEPHALOGRAPHIC MAGNETIC-RESONANCE-IMAGING STUDY
M. Hajek et al., ABNORMALITIES OF AUDITORY-EVOKED MAGNETIC-FIELDS AND STRUCTURAL-CHANGES IN THE LEFT-HEMISPHERE OF MALE-SCHIZOPHRENICS - A MAGNETOENCEPHALOGRAPHIC MAGNETIC-RESONANCE-IMAGING STUDY, Biological psychiatry, 42(7), 1997, pp. 609-616
Functional and structural changes in 10 DSM-III-R male schizophrenics
and 10 healthy volunteers were investigated using magnetoencephalograp
hically (MEG) detected long-latency (N100m) auditory evoked fields (AE
Fs) and magnetic resonance imaging (MRI), The AEFs were characterized
by single moving equivalent dipoles, which were superimposed on MRIs.
There were significant differences in dipole orientations and in AEF l
atencies in the left hemisphere of schizophrenics, when compared to th
e controls. The MEG-detected alterations were found to be associated w
ith a bilateral volume reduction of the posterior superior temporal gy
rus (pSTG), which was more pronounced in the left hemisphere, Separate
analysis of white and gray matter has shown that the pSTG volume redu
ction resulted from decreased gray matter volumes without white matter
changes. Both the functional and the morphological data indicate a le
ft-hemispheric disturbance in our patients, (C) 1997 Society of Biolog
ical Psychiatry.