SYNTHESES VIA VINYL SULFONES .75. TRIFLONE CHEMISTRY .10. SCOPE AND LIMITATIONS OF FUNCTIONALIZED ACETYLENIC TRIFLONES IN THE DIRECT ALKYNYLATION OF C-H BONDS
J. Xiang et al., SYNTHESES VIA VINYL SULFONES .75. TRIFLONE CHEMISTRY .10. SCOPE AND LIMITATIONS OF FUNCTIONALIZED ACETYLENIC TRIFLONES IN THE DIRECT ALKYNYLATION OF C-H BONDS, Tetrahedron letters, 38(38), 1997, pp. 6635-6638
Reactions of TIPS-substituted acetylenic triflones extends the versati
lity of the trifluoromethyl radical mediated C-H alkynylation reaction
, Alkynes bearing acetylenic or propargylic oxygen functionality canno
t be prepared, but silyl ethers or chlorides in remote positions may b
e carried through the reaction. Crown ethers are successfully monofunc
tionalized and distal bis-acetylenes may be employed in the title reac
tion. (C) 1997 Elsevier Science Ltd.