SOLID-PHASE SYNTHESIS OF NOVEL AMINO-ETHER DERIVATIVES

Three amino-ether derivatives have been prepared by a solid-phase synt hesis using a novel amidine-based linker. The sequence of reactions in volved a) amine exchange of a solid-supported dimethylformamidine with a secondary amine, b) alpha-alkylation of the solid-supported formami dine with an aromatic aldehyde, c) alkylation of the newly generated h ydroxyl group with a benzylic halide, and d) cleavage of the formamidi ne linkage to the solid support. (C) 1997 Elsevier Science Ltd.