STEREOSELECTIVE SYNTHESIS OF CIS-5-ALKYL-(S)-PROLINES FROM (S)-PYROGLUTAMIC ACID VIA 5-ALKYL-5-HYDROXY-(S)-PROLINES

Authors
LI H SAKAMOTO T KIKUGAWA Y
Citation
H. Li et al., STEREOSELECTIVE SYNTHESIS OF CIS-5-ALKYL-(S)-PROLINES FROM (S)-PYROGLUTAMIC ACID VIA 5-ALKYL-5-HYDROXY-(S)-PROLINES, Tetrahedron letters, 38(38), 1997, pp. 6677-6680
Citations number
27
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
38
Year of publication
1997
Pages
6677 - 6680
Database
ISI
SICI code
0040-4039(1997)38:38<6677:SSOCF(>2.0.ZU;2-O
Abstract
Introduction of alkyl groups with trialkylaluminums in the 5-position of the pyroglutamic ring system without ring opening and subsequent hy drogenation over Pt/C lead to exclusively cis-5-alkyl-(S)-prolines wit hout epimerization of the chiral centre. (C) 1997 Elsevier Science Ltd .