PREPARATION OF ARTIFICIAL GLYCOLIPIDS AND THEIR AGGREGATION BEHAVIOR IN AQUEOUS-MEDIA

Authors
HISAEDA Y OHSHIMA E KIKUCHI J MURAKAMI Y
Citation
Y. Hisaeda et al., PREPARATION OF ARTIFICIAL GLYCOLIPIDS AND THEIR AGGREGATION BEHAVIOR IN AQUEOUS-MEDIA, Tetrahedron letters, 38(38), 1997, pp. 6713-6716
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
38
Year of publication
1997
Pages
6713 - 6716
Database
ISI
SICI code
0040-4039(1997)38:38<6713:POAGAT>2.0.ZU;2-E
Abstract
N,N-Dihexadecyl-N-alpha-[6-(beta D-galactopyranosyl)hexanoyl]-L-alanin amide and N,N-dihexadecyl-N-alpha-[6-{(beta D-galactopyranosyl>(1 --> 4>O-(D-glucopyranosyl)}hexanoyl]-L-alaninamide, which have an amino ac id residue interposed between a polar sugar moiety and a hydrophobic d ouble-chain segment individually, were prepared and characterized as n ovel artificial glycolipids. Morphological studies by means of differe ntial scanning calorimetry and dynamic light scattering as well as ele ctron microscopy clarified that these lipids tend to form stable bilay er membranes by themselves in aqueous media. (C) 1997 Elsevier Science Ltd.