INHIBITION OF UDP-GAL MUTASE AND MYCOBACTERIAL GALACTAN BIOSYNTHESIS BY PYRROLIDINE ANALOGS OF GALACTOFURANOSE

Authors
LEE RE SMITH MD NASH RJ GRIFFITHS RC MCNEIL M GREWAL RK YAN WX BESRA GS BRENNAN PJ FLEET GWJ
Citation
Re. Lee et al., INHIBITION OF UDP-GAL MUTASE AND MYCOBACTERIAL GALACTAN BIOSYNTHESIS BY PYRROLIDINE ANALOGS OF GALACTOFURANOSE, Tetrahedron letters, 38(38), 1997, pp. 6733-6736
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
38
Year of publication
1997
Pages
6733 - 6736
Database
ISI
SICI code
0040-4039(1997)38:38<6733:IOUMAM>2.0.ZU;2-Z
Abstract
Some pyrrolidine analogues of galactofuranose - synthesised from carbo hydrate lactones - are the first known inhibitors of E. coli K12 UDP-G al mutase and mycobacterial galactan biosynthesis.:This inhibition may form a new chemotherapeutic strategy for the treatment of human patho gens which contain integral galactofuranosyl structures such as tuberc ulosis and leprosy. (C) 1997 Elsevier Science Ltd.