DINUCLEOSIDE MONOPHOSPHATE ANALOGS CONTAINING DISULFIDE LINKAGES

Authors
WITCH EM COSSTICK R
Citation
Em. Witch et R. Cosstick, DINUCLEOSIDE MONOPHOSPHATE ANALOGS CONTAINING DISULFIDE LINKAGES, Tetrahedron letters, 38(38), 1997, pp. 6745-6748
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
38
Issue
38
Year of publication
1997
Pages
6745 - 6748
Database
ISI
SICI code
0040-4039(1997)38:38<6745:DMACDL>2.0.ZU;2-H
Abstract
The synthesis of two dinucleoside monophosphate analogues is described in which the 3'-O-P-O-5' phosphodiester linkage is replaced by either an isosteric 3'-C-S-S-5' or a shorter 3'-S-S-5' linkage. In both case s the -S-S- bond was formed through a disulfide exchange reaction usin g an activated S-nucleosidyl S-aryl disulfide and a suitably protected derivative of 5'-thiothymidine. (C) 1997 Elsevier Science Ltd.