A RANEY NICKEL-SODIUM HYPOPHOSPHITE COMBINATION SYSTEM FOR REDUCTIVE DESULFURIZATION WITHOUT RACEMIZATION OF OPTICALLY-ACTIVE SECONDARY ALCOHOL

Authors
NODE M NISHIDE K SHIGETA Y OBATA K SHIRAKI H KUNISHIGE H
Citation
M. Node et al., A RANEY NICKEL-SODIUM HYPOPHOSPHITE COMBINATION SYSTEM FOR REDUCTIVE DESULFURIZATION WITHOUT RACEMIZATION OF OPTICALLY-ACTIVE SECONDARY ALCOHOL, Tetrahedron, 53(38), 1997, pp. 12883-12894
Citations number
38
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
53
Issue
38
Year of publication
1997
Pages
12883 - 12894
Database
ISI
SICI code
0040-4020(1997)53:38<12883:ARNHCS>2.0.ZU;2-0
Abstract
Sulfides and sulfoxides bearing an optically active secondary alcohol were desulfurized with a Raney nickel (W-2)-sodium hypophosphite combi nation system to give optically active alcohols in high yields without racemization. However, the combination system was not effective with sulfides which comprise an alkylthio group and the corresponding sulfo xides. This system exhibited the reductive desulfurization of benzylth io or phenylthio ether in the presence of a benzyl ether. (C) 1997 Els evier Science Ltd.