GLYCOSIDASE-INHIBITING PYRROLIDINE ALKALOIDS FROM HYACINTHOIDES NON-SCRIPTA

The glycosidase-inhibiting pyrrolidine alkaloids ,5R)-2,5-dihydroxymet hyl-3,4-dihydroxy-pyrrolidine (DMDP), 2,5-dideoxy-2,5-imino-DL-glycero -D-manno-heptitol (homoDMDP), homoDMDP-7-O-apioside and 1,4-dideoxy-1, 4-imino-D-arabinitol have been identified in the leaves of bluebells ( Hyacinthoides non-scripta). HomoDMDP and homoDMDP-7-O-apioside are new natural products. Glycosidase inhibition by the aglycones is compared and could explain the symptoms of poisoning of livestock by bluebells . (C) 1997 Elsevier Science Ltd.