HEPATOSPLENIC GAMMA DELTA T-CELL LYMPHOMA - A REPORT OF 2 CASES IN IMMUNOCOMPROMISED PATIENTS, ASSOCIATED WITH ISOCHROMOSOME 7Q/

Two cases of peripheral T-cell lymphoma, characterized by hepatospleni c presentation and gamma/delta T-cell receptor phenotype on malignant cells, are reported. Little is known about the chromosomal changes in these peculiar lymphomas. We report the cytogenetic analysis of these two patients. Isochromosome 7q and trisomy 8 were observed. These abno rmalities were reported previously in five cases of gamma/delta T-cell lymphoma. These two patients had lymphomatous infiltration of the spl een, liver, bone marrow, and (in one case) lymph nodes. These abnormal ities occurred in immunocompromised patients (i.e., immunosuppressive therapy for kidney transplantation and chemotherapy for Hodgkin's dise ase), without Epstein-Barr virus infection stigmata in tumor cells.