Background. Headaches are a common entity in the ambulatory population
. Physicians involved in sports medicine must be able to accurately, d
iagnose headaches in athletes and whether they are exacerbated by exer
tion. Many medications have proven or theoretical negative effects on
athletic performance. Thus, we should consider all aspects of medical
management and determine which therapy is least intrusive to die athle
te's performance. We planned this review because of the small number o
f papers available on the effects of various medications on athletic p
erformance. Methods. We used MEDLINE to search from 1992 to current ci
tations, using the medical subject headings of headache, prophylaxis,
treatment, review, athletes, and exercise, alone or in combination. Re
sults. Fifty-two articles were identified and deemed appropriate for i
nclusion in this review. Conclusions. Acute therapy for tension headac
hes in the athletic population is best done with nonsteroidal anti-inf
lammatory drugs. Prophylaxis of chronic, recurrent tension headaches i
s best accomplished by night-time tricyclic antidepressants (especiall
y nortriptyline) or selective serotonin reuptake inhibitors. Acute the
rapy for athletes with migraines is best managed with sumatriptan or D
HE 45 and prophylaxis can be accomplished with verapamil, antidepressa
nts, or valproate. Exertional, cluster, and structural/infectious head
aches are also discussed briefly.